FITC标记的大肠癌肿瘤突变蛋白抗体
产品名称： FITC标记的大肠癌肿瘤突变蛋白抗体
英文名称： Anti-MCC/FITC
产品编号： HZ-6072R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MCC/FITC Conjugated antibody
FITC标记的大肠癌肿瘤突变蛋白抗体
| 英文名称 | Anti-MCC/FITC |
| 中文名称 | FITC标记的大肠癌肿瘤突变蛋白抗体 |
| 别 名 | Colorectal mutant cancer protein; MCC 1; MCC-1; MCC1; Mutated in colorectal cancers; Protein MCC; CRCM_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 93kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MCC. |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Subunit: Interacts with SCRIB, EZR, SNX27, SLC9A3R1 and SLC9A3R2. Interacts with CTNNB1; the interaction is enhanced upon Wnt stimulation. Subcellular Location: Cell membrane. Nucleus. Cytoplasm. Tissue Specificity: Expressed in a variety of tissues. Similarity: Belongs to the MCC family. Database links: UniProtKB/Swiss-Prot: P23508.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因是一种候选的大肠肿瘤抑制基因，被认为负调控细胞周期进程。小鼠中的同源基因表达与质膜和膜细胞器相关的磷蛋白，并且小鼠蛋白的过度表达抑制进入S期。该基因已发现编码不同亚型的多个转录变体。[ RefSeq，JUL 2008 ]提供。