Notch信号靶标基因表达PCR芯片

 Notch信号靶标基因表达PCR芯片可用于研究Notch信号转导的84个关键应答基因的表达。该芯片包含了Notch经典信号通路的转录因子和研究验证得到的高关联性靶标基因，通过该芯片得到的结果可用于Notch信号传导激活和抑制研究。利用该芯片研究者即能够利用该芯片简单可靠地同时检测Notch调节的细胞活动相关基因的表达。

Cell Fate Commitment: DKK1, HES1, HES5, JAG1, NODAL, NOTCH1, NOTCH3, PAX6, RUNX2, SOX9.

Developmental Processes: Embryonic Development: DKK1, EDN1, EFNB1, FOXC1, FOXD3, FOXF1, HES1, HES7, MYF5, NODAL, NOTCH1, PBX1, PCDH8, PDGFRA, PDGFRB, RBPJ, TCF15, VEGFA, WNT4, WNT5A.

Muscle Development: EDN1, EGR3, FOXC1, HBEGF (DTR), HEY2, IGFBP3, JAG1, MYF5, NOTCH1, PDGFB, PDGFRB, TNC.

Epidermis Development: JAG1, KRT14, NOTCH1, PTGS2 (COX2), SNAI1 (SNAIL), SOX9,

TCF15.

Immune System Development: ID2, JAG1, JUN, KITLG, PBX1, RUNX1 (AML1), SGPL1, VEGFA.

Nervous System Development: BDNF,

CCND2, DKK1, DTX1, EFNA1, EFNB1, EGR3, FABP7, FOXC1, HES1, HES5, HEY1, HEY2, HEYL, ID3, ID4, JAG1, KALRN, NES, NODAL, NOTCH1, NOTCH3, PAX6, PBX1, RBPJ, RND1, VEGFA.

Vasculature Development: EDN1, EFNA1, FLT1, FOXC1, FOXF1, HEY2, ID1, JAG1, JUN, NODAL, NOTCH1, RBPJ, RUNX1 (AML1), SGPL1, VEGFA.

Kidney Development: ADAMTS1, BDNF, FOXC1, PBX1, PDGFRB, SGPL1.

Other Development: NRARP, S1PR3.

Signal Transduction: Notch PAthway: CREBBP (CBP), DTX1, FOXC1, HES1, HES7, HEY1, HEY2, HEYL, JAG1, LFNG, NOTCH1, NOTCH3, RBPJ, RBPJL, SNW1 (SKIIP).

WNT PAthway: CCND1, DKK1, FRZB (FRP-3), FZD5, WISP1, WNT4, WNT5A, WNT6.

Apoptosis: ABL1, BDNF, FOXC1, GADD45B, ID3, IGFBP3, JUN, KALRN, NOTCH1, PTCRA, PTGS2 (COX2), SGPL1, SOCS3, SOX9, VEGFA.

Cytokines: CX3CL1, CXCL12 (SDF1), CXCL2, IL33, NAMPT.

Transcription Factors: CBFA2T3, CLOCK, CREBBP (CBP), EGR3, FOXC1, FOXD3, FOXF1, HEY1, HEY2, HEYL, JUN, MSC, MYF5, NOTCH1, PAX6, PBX1, RBPJ, RBPJL, RUNX1 (AML1), RUNX2, SOX9, TCF15.

Other Genes: FJX1, GPSM2, HSPB8, MARK1, RHOV, TEC.