FITC标记的磷脂酰肌醇PREX2抗体
产品名称： FITC标记的磷脂酰肌醇PREX2抗体
英文名称： Anti-PREX2/FITC
产品编号： HZ19960R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-PREX2/FITC Conjugated antibody
FITC标记的磷脂酰肌醇PREX2抗体
| 英文名称 | Anti-PREX2/FITC |
| 中文名称 | FITC标记的磷脂酰肌醇PREX2抗体 |
| 别 名 | 5)-dependent Rac exchanger 2; 5-trisphosphate-dependent Rac exchanger 2 protein; 6230420N16Rik; DEP domain-containing protein 2; DEP.2; DEPDC2; FLJ12987; P-Rex2; Phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; PREX2; PREX2_HUMAN; PtdIns(3; PtdIns(3,4,5)-dependent Rac exchanger 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 183kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PREX2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | Function: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. Subunit: Interacts with RAC1. Tissue Specificity: Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. Similarity: Contains 2 DEP domains. Contains 1 DH (DBL-homology) domain. Contains 2 PDZ (DHR) domains. Contains 1 PH domain. Database links: Entrez Gene: 80243 Human Entrez Gene: 109294 Mouse Entrez Gene: 312912 Rat Omim: 612139 Human SwissProt: Q70Z35 Human SwissProt: Q3LAC4 Mouse Unigene: 591867 Human Unigene: 123247 Mouse Unigene: 229579 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
作为RAC1鸟嘌呤核苷酸交换因子（GEF）的功能，通过交换游离GTP的结合GDP来激活RAC蛋白。磷脂酰肌醇-3，4，5-三磷酸和异三聚G蛋白的βγ亚基协同激活其活性。介导RAC1的激活依赖于PI3K依赖性。可能是Rac信号传导的重要媒介，直接作用于G蛋白偶联受体和磷酸肌醇3激酶的下游。