TGT's OsteoGen bone bioreactors impart perfusion through cell seeded cylindrical scaffolds. Applications include investigating cell function, modulating the growth and development of engineered tissues, or acting as a test bed for drug and regenerative medicine technologies. Researchers are currently utilizing these systems in a wide range of research areas including: • Bone stem cell phenotype research • Mineral deposition of marrowstromal cells 1O OsteoGen The 1O system has been designed as a single sample bioreactor system that is able to support a wide range of cell and tissue growth experiments. This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. Optional features such as: transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accomodate the research application. 12O OsteoGen The 12O system has been designed as a single sample multi-chamber bioreactor system that is able to support a wide range of cell and tissue growth experiments via user defined stimulation protocols. This chamber can accommodate a single sample with a maximum size of 10 mm diameter x 10 mm thick. A custom manifold integrates up to 12 chambers with individual flow loops. Optional features such as; transducers, non-contact micrometers, pressure sensors, etc., and/or modules to customize the instrument to specific needs can be added to accomodate the research application. BONE Key: S=Standard, A=Available, - = not available CHAMBERS 1O 12O Individual growth chamber S S 12 parallel growth chambers - A Max construct size: 6 mm diameter by 10 mm long S S STIMULATION Pulsatile fluid flow stimulator A A CONTROLS Controller software, computer, and monitor - - Power supplies and cabling - - Mean flow control A A Dynamic flow control - - TISSUE MONITORING Non-contact flow sensors A A Catheter pressure transducers A A ACCESSORIES Media reservoir S S Incubator A A BENEFITS All-autoclavable components S S Excellent sample access S S Medium change without operning chamber via luer fittings S S Increased sterility with fast and clean sample change and access S S Lightweight design for easy handling S S Easily cleaned surface finishes S S Compact design for fit in standard incubators S S 100% satisfaction guaranteed warranty S S