Recombinant Human Tumor Necrosis Factor- alpha Variant
产品名称： Recombinant Human Tumor Necrosis Factor- alpha Variant
英文名称： Recombinant Human Tumor Necrosis Factor- alpha Variant
产品编号： 103-01V
产品价格： 0
产品产地： 美国
品牌商标： sciencell
更新时间： 2024-11-14T09:23:14
使用范围： null
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产品：重组人肿瘤坏死因子-αVariant
货号：103-01V
| Description | The clinical use of the potent antitumor activity of TNF-α has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-α55 but not to the murine TNF-α75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-α55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo. |
| Synonyms | DIF, TNFA, TNFSF2, TNF-alpha |
| Source | Escherichia coli |
| Molecular Weight | Approximately 16 kDa, a single non-glycosylated polypeptide chain containing 151 amino acids. |
| Biological Activity | Fully biologically active. Specific activity ? 1.0 |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated (1mg/ml) solution in PBS, pH 7.0. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
| Storage | Store at -20°C after receiving. Upon Reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Usage | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Growth Factors and Cytokines | ||||
| Human Growth Factors | ||||
| 102-01 | rhSCF | 重组人干细胞因子 | Recombinant Human Stem Cell Factor | 2µg |
| 102-02 | rhG-CSF | 重组人粒细胞集落刺激因子 | Recombinant Human Granulocyte Colony Stimulating Factor | 2µg |
| 102-03 | rhGM-CSF | 重组人粒细胞巨噬细胞集落刺激因子 | Recombinant Human Granulocyte Macrophage Colony Stimulating Factor | 5µg |
| 102-09 | rhM-CSF | 重组人巨噬细胞集落刺激因子 | Recombinant Human Macrophage Colony Stimulating Factor | 2µg |
| 103-01 | rhTNF-α | 重组人肿瘤坏死因子-α | Recombinant Human Tumor Necrosis Factor-alpha | 10µg |
| 103-01H | rhTNF-α-His | 重组人肿瘤坏死因子-α,His | Recombinant Human Tumor Necrosis Factor-alpha,His | 10µg |
| 103-01V | rhTNF-α Vari | 重组人肿瘤坏死因子-αVariant | Recombinant Human Tumor Necrosis Factor- alpha Variant | 10µg |
| 103-04 | rhBAF | 重组人B细胞活化因子 | Recombinant Human B Cell Activating Factor | 5µg |
| 103-08 | rhOSM | 重组人抑瘤素-M | Recombinant Human Oncostatin-M | 2µg |
| 103-08T | rhOSM 209a.a. | 重组人抑瘤素-M209a.a. | Recombinant Human Oncostatin-M 209a.a. | 2µg |
| 103-09 | rhAK1-3 | 重组人血管抑素K1-3 | Recombinant Human Angiostatin K1-3 | 10µg |
| 103-12 | rhEndostatin | 重组人血管内皮抑素 | Recombinant Human Endostatin | 2µg |
| 104-01 | rhaFGF | 重组人碱性成纤维细胞生长因子--酸性 | Recombinant Human Fibroblast Growth Factor- acidic | 10µg |
| 104-02 | rhbFGF | 重组人碱性成纤维细胞生长因子--碱性 | Recombinant Human Fibroblast Growth Factor-basic | 10µg |
| 104-07 | rhKGF-1 | 重组人角质细胞生长因子-1 | Recombinant Human Keratinocye Growth Factor-1 | 2µg |
| 104-09 | rhFGF-9 | 重组人成纤维细胞生长因子-9 | Recombinant Human Fibrobalst Growth Factor-9 | 5µg |
| 104-10 | rhKGF-2 | 重组人角质细胞生长因子-2 | Recombinant Human Keratinocye Growth Factor-2 |
5µg |
| 104-19 |
rhFGF-19 | 重组人成纤维细胞生长因子-19 | Recombinant Human Fibrobalst Growth Factor-19 |
5µg |
| 104-21 |
rhFGF-21 | 重组人成纤维细胞生长因子-21 | Recombinant Human Fibrobalst Growth Factor-21 |
5µg |
| 105-01 |
rhIGF-I | 重组人IGF-I | Recombinant Human IGF-I |
20µg |
| 105-01B |
rHuDES1-3/IGF1 | 重组人 DES1-3/ 胰岛样生长因子 -1 | Recombinant Human DES1-3/ Insulin-Like Growth factor 1 |
20μg |
| 105-01B3 |
rhIGF-BP3 | 重组人 IGF-BP3 | Recombinant Human IGF-BP3 |
5µg |
| 105-03 |
rhLR3IGF-1 | 重组人长R3胰岛样生长因子-1 | Recombinant Human Long R3 Insulin-like Growth factor-1 |
20µg |
| 105-04 |
rhEGF | 重组人表皮细胞生长因子 | Recombinant Human Epidermal Growth Factor |
100µg |
| 105-05 |
rhVEGF165 | 重组人血管内皮生长因子165 | Recombinant Human VEGF165 |
2µg |
| 107-04 |
rhNT-4 | 重组人神经营养因子-4 | Recombinant Human Neurotrophin-4 |
2µg |
| 107-08 | rhCNTF | 重组人睫状神经营养因子 | Recombinant Human Ciliary Neurotrophic Factor |
5µg |
| 107-10 |
rhNRG-1 | 重组人 NRG-1（表皮生长因子样结构域） | Recombinant Human NRG-1(EGF-like domain) |
10µg |
| 107-11 |
rhErbB3-f | TUNEology 波长可调检测卡盒-->
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