FITC标记的丝裂原活化蛋白激酶3K9抗体
产品名称： FITC标记的丝裂原活化蛋白激酶3K9抗体
英文名称： Anti-MAP3K9/FITC
产品编号： HZ-10424R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MAP3K9/FITC Conjugated antibody
FITC标记的丝裂原活化蛋白激酶3K9抗体
| 英文名称 | Anti-MAP3K9/FITC |
| 中文名称 | FITC标记的丝裂原活化蛋白激酶3K9抗体 |
| 别 名 | MLK1; M3K9_HUMAN; Map3k9; MEKK9; Mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 1; PRKE1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 122kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAP3K9 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Mixed lineage kinases are a family of protein kinases sharing two leucine zipper-like motifs, which are known to mediate protein dimerization, and a kinase domain whose primary structure is similar to both the tyrosine-specific and the serine/threonine-specific kinase classes. Members of the mixed-lineage kinase (MLK) family include MLK1, MLK2, MLK3 and dual leucine zipper kinase, also designated DLK. MLKs are expressed in neuronal cells where they are likely to interact between Rac1/Cdc42, MKK4 and MKK7 in death signaling. The human MLK1 gene maps to chromosome 14q24.3-q31 and is expressed in epithelial tumor cell lines of the colon, breast, and esophagus. The human MLK2 gene maps to chromosome 19 q13.2. and encodes a predicted 954 amino acid, src homology 3 (SH3) domain-containing protein. The human MLK3 gene maps to chromosome 11q13.1-13.3 and encodes a 847 amino acid, SH3 domain- and proline rich region-containing protein. Apoptosis mechanisms rely on MLKs as an upstream intermediate of mitochondrial cytochrome c release and caspase activation. Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Subunit: Homodimer. Tissue Specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. Post-translational modifications: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308. DISEASE: Note=May play a role in esophageal cancer susceptibility and/or development. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain. Database links: Entrez Gene: 4293 Human Entrez Gene: 338372 Mouse Entrez Gene: 500690 Rat Omim: 600136 Human SwissProt: P80192 Human SwissProt: Q3U1V8 Mouse Unigene: 445496 Human Unigene: 593542 Human Unigene: 35284 Mouse Unigene: 18840 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
混合谱系激酶是一类蛋白激酶，具有两个已知介导蛋白二聚的亮氨酸拉链状基序，以及一个激酶结构域，其一级结构类似于酪氨酸特异性和丝氨酸/苏氨酸特异性激酶类。混合谱系激酶（MLK）家族的成员包括MLK1、MLK2、MLK3和双亮氨酸拉链激酶，也被指定为DLK。MLKs在神经元细胞中表达，它们在死亡信号中可能在RAC1/CDC42、MKK4和MKK7之间相互作用。人类MLK1基因定位于14q24.3-q31染色体，在结肠、乳腺和食管上皮性肿瘤细胞系中表达。人类MLK2基因定位于第19号染色体Q132。并编码预测的954个氨基酸，Src同源3（SH3）结构域蛋白。人类MLK3基因定位于染色体11q13.1-13.3，编码847个氨基酸、SH3结构域和富含脯氨酸的蛋白质。细胞凋亡机制依赖于MLKs作为线粒体细胞色素C释放和半胱天冬酶激活的上游中间体。