FITC标记的肿瘤坏死因子受体相关蛋白2抗体
产品名称： FITC标记的肿瘤坏死因子受体相关蛋白2抗体
英文名称： Anti-Proteasome 26S S2/FITC
产品编号： HZ-9363R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Proteasome 26S S2/FITC Conjugated antibody
FITC标记的肿瘤坏死因子受体相关蛋白2抗体
| 产品编号 | bs-9363R-FITC |
| 英文名称 | Anti-Proteasome 26S S2/FITC |
| 中文名称 | FITC标记的肿瘤坏死因子受体相关蛋白2抗体 |
| 别 名 | 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; MGC14274; P97 antibody Proteasome (prosome macropain) 26S subunit non ATPase 2; Protein 55.11; Psmd2; PSMD2_HUMAN; Rpn1; S2 antibody TNFR associated protein 2; TRAP2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2; proteasome 26S subunit, non-ATPase 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 100kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Proteasome 26S S2/TRAP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. Tissue Specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta. Similarity: Belongs to the proteasome subunit S2 family. Contains 7 PC repeats. Database links: Entrez Gene: 5708 Human Entrez Gene: 21762 Mouse Entrez Gene: 287984 Rat Omim: 606223 Human SwissProt: Q13200 Human SwissProt: Q8VDM4 Mouse SwissProt: Q4FZT9 Rat Unigene: 518464 Human Unigene: 243234 Mouse Unigene: 29909 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
26S蛋白酶体是由2个复合物、20S核心和19S调节器组成的高度有序结构的多金属蛋白酶复合物。20S核由28个不相同的亚基组成的4个环，2个环由7个α亚基组成，2个环由7个β亚基组成。19S调节剂由一个碱基组成，它含有6个ATPase亚基和2个非ATP酶亚基，和一个含有最多10个非ATPase亚基的盖子。蛋白酶体在高浓度的真核细胞中分布，在非溶酶体途径中ATP／泛素依赖的过程中裂解肽。一种修饰的蛋白酶体，免疫蛋白酶体的基本功能，是I类MHC肽的加工。该基因编码19S调节器盖的非ATP酶亚基之一。除了参与蛋白酶体功能外，该亚基还参与TNF信号传导通路，因为它与肿瘤坏死因子1型受体相互作用。在第1号染色体上已鉴定出假基因。选择性剪接导致该基因的多个转录变体。[ RefSeq，JUL 2013 ]