FITC标记的细胞外基质磷酸化抗体
产品名称： FITC标记的细胞外基质磷酸化抗体
英文名称： Anti-MEPE/FITC
产品编号： HZ-8689R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MEPE/FITC Conjugated antibody
FITC标记的细胞外基质磷酸化抗体
| 产品编号 | bs-8689R-FITC |
| 英文名称 | Anti-MEPE/FITC |
| 中文名称 | FITC标记的细胞外基质磷酸化抗体 |
| 别 名 | Matrix extracellular phosphoglycoprotein; MEPE; MEPE_HUMAN; OF45; Osteoblast/osteocyte factor 45. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 发育生物学 信号转导 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MEPE |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MEPE is a 525 amino acid extracellular matrix protein. Expressed in osteocytes and brain, MEPE is a regulator of bone metabolism that is thought to mediate mineralization and demineralization within the osteocyte microenvironment. MEPE contains an RGD cell-attachment motif and shares molecular similarities with several dentin-bone extracellular matrix RGD-containing phosphoglycoproteins, including OPN (osteopontin) and DSP (dentin sialophosphoprotein). Via its ability to control bone mineralization, MEPE is associated with various developmental events such as skeletogenesis, bone regeneration and odontogenesis. MEPE is secreted in hypophosphatemic osteomalacia tumors, suggesting a possible role in the pathophysiology of bone-related cancers. Function: Seems to play a role in mineralization. Subcellular Location: Secreted Tissue Specificity: Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors. Post-translational modifications: Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif. Database links: Entrez Gene: 56955 Human Entrez Gene: 94111 Mouse Entrez Gene: 79110 Rat Omim: 605912 Human SwissProt: Q9NQ76 Human Unigene: 676357 Human Unigene: 196672 Mouse Unigene: 160717 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MEPE是一种525氨基酸的细胞外基质蛋白。在骨细胞和脑中表达，MEPE是骨代谢的调节器，被认为介导骨细胞微环境中矿化和脱矿。MEPE含有RGD细胞附着基序，与含有磷酸化糖蛋白的多个牙本质骨细胞外基质RGD具有分子相似性，包括OPN（骨桥蛋白）和DSP（牙本质涎磷蛋白）。通过其控制骨矿化的能力，MEPE与各种发育事件相关，如骨骼生成、骨再生和牙发育。MEPE在低磷酸盐血症骨软化瘤中分泌，提示在骨相关癌症的病理生理学中可能发挥作用。