FITC标记的磷酸化系统性红斑狼疮相关蛋白TREX1抗体
产品名称： FITC标记的磷酸化系统性红斑狼疮相关蛋白TREX1抗体
英文名称： Anti-Phospho-ATRIP (Ser224)/FITC
产品编号： HZ-11225R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Phospho-ATRIP (Ser224)/FITC Conjugated antibody
FITC标记的磷酸化系统性红斑狼疮相关蛋白TREX1抗体
| 产品编号 | bs-11225R-FITC |
| 英文名称 | Anti-Phospho-ATRIP (Ser224)/FITC |
| 中文名称 | FITC标记的磷酸化系统性红斑狼疮相关蛋白TREX1抗体 |
| 别 名 | ATRIP(Ser224); Phospho-ATRIP(Ser224); P-ATRIP (phospho-Ser224); Phospho-ATRIP (Ser224); AGS 1; AGS1; AGS-1; Aicardi Goutieres syndrome 1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; Deoxyribonuclease III dnaQ/mutD (E. coli) like; DKFZp434J0310; DKFZp762J2115; DNase III; DRN 3; DRN3; FLJ12343; MGC20625; MGC26740; Three prime repair exonuclease 1; TREX 1; TREX1; TREX1 protein; MGC21482; 3' repair exonuclease 1; 3'-5' exonuclease TREX1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 86kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human ATRIP around the phosphorylation site of Ser224 [HV(p-S)PR] |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization. Function: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Subunit: Interacts with ATR. Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP. Subcellular Location: Nucleus. Redistributes to discrete nuclear foci upon DNA damage. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated by ATR. Similarity: Belongs to the ATRIP family. Database links: Entrez Gene: 84126 Human Entrez Gene: 235610 Mouse Entrez Gene: 301014 Rat Omim: 606605 Human SwissProt: Q8WXE1 Human SwissProt: Q8BMG1 Mouse Unigene: 694840 Human Unigene: 100622 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DNA损伤或DNA的不完全复制导致细胞周期进程在G1至S或G2到M相转变的抑制，称为细胞周期检查点的保守调控机制。检查点蛋白质包括RAD17，参与调节G1检查点的细胞周期进程以及CHK1、CHK2、RAD1、RAD9和HUS1，它们参与调节G2检查点的细胞周期阻滞。响应于DNA损伤，ATM和ATR激酶对于细胞周期检查点响应信号是重要的。ATR相互作用蛋白（ATIP），也被命名为ATM和RAD3相关的相互作用蛋白，需要DNA损伤后的检查点信号。同样重要的是ATR表达，调节DNA复制和损伤检查点反应。心房蛋白是一种表达ATR的异源二聚体。二聚后，它们结合RPA复合物并被招募到单链DNA。心房是一种核蛋白，也可能在蛋白质稳定中起作用。