FITC标记的TIP60相关蛋白54α抗体
产品名称： FITC标记的TIP60相关蛋白54α抗体
英文名称： Anti-TIP49A/FITC
产品编号： HZ-19936R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TIP49A/FITC Conjugated antibody
FITC标记的TIP60相关蛋白54α抗体
| 英文名称 | Anti-TIP49A/FITC |
| 中文名称 | FITC标记的TIP60相关蛋白54α抗体 |
| 别 名 | 49 kDa TATA box binding protein interacting protein; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic protein; ECP-54; ECP54; ERYTHROCYTE CYTOSOLIC PROTEIN, 54-KD; INO80 complex subunit H; NMP 238; Nuclear matrix protein 238; Pontin 52; PONTIN; RuvB like 1; RuvB-like 1; RUVB1_HUMAN; RUVBL1; RVB1; TAP54 alpha; TAP54-alpha; TIP49; TIP49a; TIP60 associated protein 54 alpha; TIP60-associated protein 54-alpha. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIP49A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | Function: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation. Subcellular Location: Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Cytoplasm > cytoskeleton > centrosome. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. Tissue Specificity: Ubiquitously expressed with high expression in heart, skeletal muscle and testis. Similarity: Belongs to the ruvB family. Database links: Entrez Gene: 8607 Human Entrez Gene: 56505 Mouse Entrez Gene: 65137 Rat Omim: 603449 Human SwissProt: Q9Y265 Human SwissProt: P60122 Mouse SwissProt: P60123 Rat Unigene: 272822 Human Unigene: 42195 Mouse Unigene: 86410 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
具有单链DNA刺激ATP酶和ATP依赖性DNA解旋酶（3′～5′）活性。NuA4组蛋白乙酰转移酶复合物的组成部分，主要通过核小体组蛋白H4和H2A的乙酰化参与选择基因的转录激活。这种修饰可以改变核小体-DNA的相互作用并促进修饰组蛋白与其他对转录有正向调节作用的蛋白质。该复合物可能需要激活与癌基因和原癌基因介导的生长诱导、肿瘤抑制因子介导的生长阻滞和复制性衰老、凋亡和DNA修复相关的转录程序。NuA4复合ATPase和螺旋酶活性似乎至少部分由RUVBL1和RUVBL2与EP400的结合所贡献。Nua4在DNA损伤位点的修复中也起着直接的作用。RUVBL1在MYC致癌转化中起重要作用，并且还通过LEF1/TCF1-CTNNB1复合物调节转录激活。可以在细胞表面结合纤溶酶原，增强纤溶酶原激活。
细胞增殖的必要条件。