FITC标记的G蛋白偶联受体167抗体
产品名称： FITC标记的G蛋白偶联受体167抗体
英文名称： Anti-GPCR MRGE/GPCR GPR167/FITC
产品编号： HZ-16269R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GPCR MRGE/GPCR GPR167/FITC Conjugated antibody
FITC标记的G蛋白偶联受体167抗体
| 英文名称 | Anti-GPCR MRGE/GPCR GPR167/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体167抗体 |
| 别 名 | G protein coupled receptor 167; G-protein coupled receptor 167; GPR167; Mas related G protein coupled MRGE; MAS related GPR member E; Mas-related G-protein coupled receptor member E; MRGE; MRGPRE; MRGRE_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 细胞凋亡 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPCR MRGE/GPCR GPR167 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MRGE is a 311 amino acid multi-pass membrane protein that acts as an orphan receptor and is though to influence nociceptor function. A member of the G-protein coupled receptor 1 family and MAS subfamily, MRGE is encoded by a gene that maps to human chromosome 11p15.4 and mouse chromosome 7 F5. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. Database links: Entrez Gene: 116534 Human Entrez Gene: 244238 Mouse Entrez Gene: 404660 Rat Omim: 607232 Human SwissProt: Q86SM8 Human SwissProt: Q91ZB7 Mouse SwissProt: Q7TN40 Rat Unigene: 706565 Human Unigene: 183561 Mouse Unigene: 189891 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MRGE是一种311个氨基酸的多通道膜蛋白，其作为孤儿受体，并影响伤害感受器功能。MRGE是G-蛋白偶联受体1家族和MAS亚家族的成员，由映射到人染色体11p15.4和小鼠染色体7F5的基因编码。第11染色体包含大约4%的人类基因组DNA，被认为是基因和疾病关联密集染色体。编码Atm基因的11号染色体对双链DNA断裂后细胞周期阻滞和凋亡的调控具有重要意义。ATM突变导致称为共济失调毛细血管扩张症。Jervell和Lange-Nielsen综合征、Jac.n综合征、Niemann-Pick病、遗传性血管水肿和Smith-Lemli-Opitz综合征也与染色体11编码基因的缺陷有关。