FITC标记的钾/钠超极化激活环核苷酸门控通道蛋白2抗体
产品名称： FITC标记的钾/钠超极化激活环核苷酸门控通道蛋白2抗体
英文名称： Anti-HCN2/FITC
产品编号： HZ-20166R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HCN2/FITC Conjugated antibody
FITC标记的钾/钠超极化激活环核苷酸门控通道蛋白2抗体
| 英文名称 | Anti-HCN2/FITC |
| 中文名称 | FITC标记的钾/钠超极化激活环核苷酸门控通道蛋白2抗体 |
| 别 名 | BCNG-2; BCNG2; HCN 2; Brain cyclic nucleotide gated channel 2; Brain cyclic nucleotide-gated channel 2; HAC1; Hcn2; HCN2_HUMAN; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 神经生物学 信号转导 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 97kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HCN2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1–4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif (1). HCN channels are expressed in the brain, heart, thalamus and testis (1). The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart (1). The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively (2,3). The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively (4,5). Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed throughout the brain. Detected at low levels in heart. Similarity: Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. Database links: Entrez Gene: 610 Human Entrez Gene: 15166 Mouse Entrez Gene: 114244 Rat Omim: 602781 Human SwissProt: Q9UL51 Human SwissProt: O88703 Mouse SwissProt: Q9JKA9 Rat Unigene: 124161 Human Unigene: 12956 Mouse Unigene: 224995 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
超极化激活的环核苷酸结合通道(HCN)是通过细胞内环核苷酸直接结合而激活的电压门控阳离子通道。HCN家族由四个成员（HCN1-4）组成，每个成员具有核心跨膜片段结构域和羧基端120个氨基酸环核苷酸结合结构域基序（1）。HCN通道在脑、心脏、丘脑和睾丸中表达（1）。HCN通道的起搏特性有助于大脑和心脏的自发节律活动（1）。编码人HCN1和HCN2的基因分别定位于染色体5和19p13.3(2,3)。编码HCN3和HCN4的基因分别定位于1q21.3和15q24-q25染色体(4,5)。