FITC标记的GEM相互作用蛋白抗体
产品名称： FITC标记的GEM相互作用蛋白抗体
英文名称： Anti-GMIP/FITC
产品编号： HZ-13458R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GMIP/FITC Conjugated antibody
FITC标记的GEM相互作用蛋白抗体
| 英文名称 | Anti-GMIP/FITC |
| 中文名称 | FITC标记的GEM相互作用蛋白抗体 |
| 别 名 | ARHGAP46; GEM interacting protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 107kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GMIP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Rho family of GTP-binding proteins plays a role in the development of neuronal structure. The activation of the GTP-bound form is regulated by GTPase-activating proteins, which stimulate GTP hydrolysis, leading to inactivation. GMIP (Gem-interacting protein) is a 970 amino acid protein that stimulates the GTPase activity of RhoA in vitro and in vivo. GMIP interacts with Gem through its N-terminus and has a Rho GTPase-activating protein domain at its C-terminus. GMIP is able to inhibit RhoA function, leading to Actin cytoskeletal reorganization in vivo. Encoded by a gene that maps to human chromosome 19p13.11, GMIP contains one phorbol-ester/DAG-type zinc finger and one Rho-GAP domain. Function: Stimulates, in vitro and in vivo, the GTPase activity of RhoA. Subunit: Interacts with GEM through its N-terminal. Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain. Database links: Entrez Gene: 51291 Human Omim: 609694 Human SwissProt: Q9P107 Human Unigene: 49427 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Rho家族的GTP结合蛋白在神经元结构的发育中起着重要的作用。GTP结合形式的激活受到GTP酶激活蛋白的调节，该蛋白刺激GTP水解，导致失活。GMIP（GEM相互作用蛋白）是一种刺激RhoA在体外和体内的GTP酶活性的970氨基酸蛋白。GMIP通过其N-末端与GEM相互作用，并在其C-末端具有Rho GTP酶激活蛋白结构域。GMIP能够抑制RhoA功能，导致体内肌动蛋白细胞骨架重组。GMIP基因编码人染色体19p13.11，含有一个佛波酯/DAG型锌指和一个Rho-GAP结构域。