FITC标记的FCRL6蛋白抗体
产品名称： FITC标记的FCRL6蛋白抗体
英文名称： Anti-FCRL6/FITC
产品编号： HZ-16068R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FCRL6/FITC Conjugated antibody
FITC标记的FCRL6蛋白抗体
| 英文名称 | Anti-FCRL6/FITC |
| 中文名称 | FITC标记的FCRL6蛋白抗体 |
| 别 名 | Fc receptor homolog 6; Fc receptor-like 6; Fc receptor-like protein 6; Fc receptor-like protein 7; FcR-like protein 6; FcRH6; FcRL6; Fcrl6; FCRL6_HUMAN; FLJ16056; IFGP6; IgSF type I transmembrane receptor; leukocyte receptor. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 淋巴细胞 t-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FCRL6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Fc receptor homolog (FcRH) family of proteins are related to the classical Fc receptors (FcR) and belong to the immunoglobulin receptor superfamily. The proteins in the FcRH family are type I transmembrane glycoproteins and consist of FcRH1-FcRH6. The genes encoding the human FcRH proteins map to chromosome 1, near the related FCR genes. The FcRH proteins, which are involved in immune system regulation, have immunoreceptor-tyrosine inhibitory motifs in their cytoplasmic domains. Mutations in the gene encoding for the FcRH proteins may be associated with systemic lupus erythematosus, autoimmune thyroid disease and rheumatoid arthritis. The FcRH genes are expressed primarily, although not exclusively, by mature B lineage cells, and may serve important regulatory roles in normal and neoplastic B cell development. Subunit: Interacts with PTPN11. Subcellular Location: Membrane. Tissue Specificity: Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells. Post-translational modifications: Phosphorylated on Tyr residue, inducing association with PTPN11. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 343413 Human Omim: 613562 Human SwissProt: Q6DN72 Human Unigene: 196955 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Fc受体同源物（FcRH）家族与经典Fc受体（FcR）有关，属于免疫球蛋白受体超家族。FcRH家族中的蛋白质是I型跨膜糖蛋白，由FCRH1-FCRH6组成。编码人类FCRH蛋白的基因映射到1号染色体上，接近相关的FCR基因。FcRH蛋白参与免疫系统的调控，其胞浆结构域具有免疫受体-酪氨酸抑制基序。FcRH蛋白编码基因的突变可能与系统性红斑狼疮、自身免疫性甲状腺疾病和类风湿性关节炎有关。FcRH基因主要由成熟B系细胞表达，但并非唯一，在正常和肿瘤B细胞发育中可能起着重要的调节作用。