FITC标记的Malectin蛋白抗体
产品名称： FITC标记的Malectin蛋白抗体
英文名称： Anti-Malectin/MLEC/FITC
产品编号： HZ-18639R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Malectin/MLEC/FITC Conjugated antibody
FITC标记的Malectin蛋白抗体
| 英文名称 | Anti-Malectin/MLEC/FITC |
| 中文名称 | FITC标记的Malectin蛋白抗体 |
| 别 名 | KIAA0152; Malectin; Mlec; MLEC_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Turkey |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Malectin/MLEC |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MLEC is a 292 amino acid single-pass type I membrane protein of the endoplasmic reticulum that belongs to the malectin family and is thought to play a role in N-glycosylation. MLEC may function as a carbohydrate-binding protein that preferentially binds Glc2-N-glycan. The gene encoding MLEC maps to human chromosome 12, which makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster, encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms which vary in severity depending on the extent of mosaicism. It is most severe in cases of complete trisomy. Function: Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation. Subcellular Location: Endoplasmic reticulum membrane. Similarity: Belongs to the malectin family. Database links: Entrez Gene: 9761 Human Entrez Gene: 109154 Mouse Entrez Gene: 304543 Rat Entrez Gene: 569613 Zebrafish Omim: 613802 Human SwissProt: Q14165 Human SwissProt: Q6ZQI3 Mouse SwissProt: Q5FVQ4 Rat SwissProt: A9C3P0 Zebrafish Unigene: 728853 Human Unigene: 153963 Mouse Unigene: 162140 Rat Unigene: 148402 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MLEC是内质网中一个292个氨基酸的单程I型膜蛋白，属于马来菌素家族，被认为在N-糖基化中起作用。MLEC可作为优先结合GLC2-N-聚糖的碳水化合物结合蛋白。编码MLEC的基因映射到人类12号染色体，约占人类基因组的4.5%。许多骨骼畸形与12号染色体相连，包括软骨发育不良、软骨发育不全和最不典型增生。诺南综合征，包括心脏和面部发育缺陷的主要症状，是由突变形式的PTPN11基因产物SH-PTP2引起的。染色体12也是同源盒基因簇和自然杀伤复合基因簇的家园，同源盒基因簇编码形态发生的关键转录因子，而自然杀伤复合基因簇编码C型凝集素，该C型凝集素蛋白介导NK细胞对MHC I相互作用的反应。12p三体导致面部发育缺陷、癫痫发作障碍和一系列其他症状，其严重程度取决于镶嵌的程度。完全三体的情况最为严重。