重组人IL-1R2(IL-1 RII)(C端带Fc标签)

中文名称：重组人IL-1R2(IL-1 RII)(C端带Fc标签)
英文名称：Recombinant Human Interleukin-1 receptor type 2/IL-1R-2
产品规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Phe14-Glu343在C端带有Fc标签。

IL-1R2/IL-1 RII质量控制：＞95%(还原性SDS-PAGE)

IL-1R2/IL-1 RII制剂：冻干品

IL-1R2/IL-1 RII保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IL-1R2/IL-1 RII复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IL-1R2/IL-1 RII：
Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. 

特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！