Pim-1 Kinase (Human) Assay/Inhibitor Screening Assay Kit
产品名称: Pim-1 Kinase (Human) Assay/Inhibitor Screening Assay Kit
英文名称: Pim-1 Kinase (Human) Assay/Inhibitor Screening Assay Kit
产品编号: KA0069
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
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- Specification
- Product Description:
- Pim-1 Kinase (Human) Assay/Inhibitor Screening Assay Kit is a single-site, non-quantitative immunoassay for Pim-1 activity. Plates are pre-coated with a substrate corresponding to recombinant p21waf1, which contains threonine residues that can be efficiently phosphorylated by Pim-1. The detector antibody specifically detects only the phosphorylated form of threonine145 residue on p21waf1.
- Reactivity:
- Human
- Storage Instruction:
- Store the kit at 4°C.
- Quality Control Testing:
- Dose dependent curve
Dose dependent curve of recombinant Pim-1 enzyme reaction.
- Protocol:
- Protocol Download
- Regulation Status:
- For research use only (RUO)
- Publication Reference
- 1.
- Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.
Hsu JL, Leong PK, Ho YF, Hsu LC, Lu PH, Chen CS, Guh JH.Cancer Lett. 2012 Jan 17. [Epub ahead of print]
- Application Image
- Functional Study
- Entrez GeneID:
- 5292
- Gene Name:
- PIM1
- Gene Alias:
- PIM
- Gene Description:
- pim-1 oncogene
- Omim ID:
- 164960
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer (Dhanasekaran et al., 2001 [PubMed 11518967]).[supplied by OMIM
- Other Designations:
- OTTHUMP00000018046,Oncogene PIM1,non-specific serine/threonine protein kinase,pim-1 kinase 44 kDa isoform,pim-1 oncogene (proviral integration site 1)
- Gene Pathway
- Related Disease
- Abortion, Spontaneous
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hodgkin Disease
- Leukemia, Myeloid, Acute
- Lung Neoplasms
- Lymphoma, B-Cell
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse
- Lymphoproliferative Disorders
- Occupational Diseases
- Prostate cancer
- Pulmonary Disease, Chronic Obstructive
- Translocation, Genetic
- Urinary Bladder Neoplasms
- Waldenstrom Macroglobulinemia
- Werner syndrome