FITC标记的胰腺特异转录因子PTF1A抗体
产品名称： FITC标记的胰腺特异转录因子PTF1A抗体
英文名称： Anti-PTF1A/FITC
产品编号： HZ-11930R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PTF1A/FITC Conjugated antibody
FITC标记的胰腺特异转录因子PTF1A抗体
| 英文名称 | Anti-PTF1A/FITC |
| 中文名称 | FITC标记的胰腺特异转录因子PTF1A抗体 |
| 别 名 | PTF1-p48; bHLH transcription factor p48; bHLHa29; Class A basic helix-loop-helix protein 29; Class II bHLH protein PTF1A; Exocrine pancreas specific transcription factor p48; p48 DNA binding subunit of transcription factor PTF1; p48 DNA-binding subunit of transcription factor PTF1; Pancreas specific transcription factor 1a; Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; PTF 1A; PTF1 p48; PTF1-p48; Ptf1a; PTF1A_HUMAN; PTF1P48. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTF1A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20∑C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ∑C. |
| 产品介绍 | background: PTF1 is a pancreas-specific protein that functions as a component of the trimeric pancreas transcription factor 1 (PTF1) complex. Localizing to the nucleus, PTF1 contains one basic helix-loop-helix (bHLH) domain and is believed to play an important role in mammalian pancreatic development, functioning as a transcription factor that regulates the specification of all three pancreatic cell types. PTF1 interacts with RBP-Jⅹ and, together, they cooperate in regulating the expression of PDX-1 (pancreas/duodenum homeobox protein 1), a key regulator of pancreatic islet development and insulin gene transcription in beta-cells. Loss of functional PTF1 can cause pancreatic progenitors to take on the normal fates of duodenal epithelia. Mutations in the gene encoding PTF1 lead to diabetes mellitus and cerebellar hypoplasia/agenesis, suggesting that PTF1 also plays and important role in cerebellar neurogenesis. Function: Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Subcellular Location: Nucleus. Cytoplasm. In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex. Tissue Specificity: Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers. DISEASE: Defects in PTF1A are the cause of diabetes mellitus and cerebellar hypoplasia/agenesis (DMCH) [MIM:609069]. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 256297 Human Entrez Gene: 19213 Mouse Entrez Gene: 117034 Rat Omim: 607194 Human SwissProt: Q7RTS3 Human SwissProt: Q9QX98 Mouse SwissProt: Q64305 Rat Unigene: 351503 Human Unigene: 69647 Mouse Unigene: 10536 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
PTF1是胰腺特异性蛋白，其功能是三聚体胰腺转录因子1（PTF1）复合物的一个组成部分。PTF1定位于细胞核，包含一个基本的螺旋-环-螺旋（bHLH）结构域，被认为在哺乳动物胰腺发育中起重要作用，作为调节所有三种胰腺细胞类型的规范的转录因子。PTF1与RBP-J相互作用，共同调节胰腺/十二指肠同源盒蛋白1（PDX-1）的表达，PDX-1是胰岛发育和胰岛β细胞胰岛素基因转录的关键调节因子。功能性PTF1的丧失可导致胰腺祖细胞接受正常的十二指肠上皮细胞命运。PTF1基因突变导致糖尿病和小脑发育不良/发育不全，提示PTF1在小脑神经发生中也发挥着重要作用。