FITC标记的促代谢型谷氨酸受体1抗体
产品名称： FITC标记的促代谢型谷氨酸受体1抗体
英文名称： Anti-GRM1/FITC
产品编号： HZ-1803R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GRM1/FITC Conjugated antibody
FITC标记的促代谢型谷氨酸受体1抗体
| 英文名称 | Anti-GRM1/FITC |
| 中文名称 | FITC标记的促代谢型谷氨酸受体1抗体 |
| 别 名 | glutamate receptor metabotropic 1; Gprc1a; Glutamate Receptor Metabotropic 1; Mglur1; Metabotropic glutamate receptor 1; mGluR1; GPRC1A; MGLUR1; GRM1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 130kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GRM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq]. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Subunit: Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Subcellular Location: Cell membrane; Multi-pass membrane protein. DISEASE: Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13) [MIM:614831]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the G-protein coupled receptor 3 family. Database links: Entrez Gene: 2911 Human Entrez Gene: 14816 Mouse Entrez Gene: 24414 Rat Omim: 604473 Human SwissProt: Q13255 Human SwissProt: P97772 Mouse SwissProt: P23385 Rat Unigene: 32945 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
L-谷氨酸是中枢神经系统的主要兴奋性神经递质，可激活离子型和代谢型谷氨酸受体。谷氨酸能神经传递涉及正常脑功能的大部分方面，并且可能在许多神经病理条件下受到干扰。代谢型谷氨酸受体是一类G蛋白偶联受体，根据序列同源性、信号转导机制和药理学性质可分为三类。第一组包括GRM1和GRM5，这些受体已被证明能激活磷脂酶C。第二组包括GRM2和GRM3，而第三组包括GRM4、GRM6、GRM7和GRM8。II组和III组受体与环AMP级联的抑制有关，但其激动剂选择性不同。代谢型谷氨酸受体1基因的典型α亚型是二硫键连接的同型异构体，其活性由G蛋白偶联的磷脂酰肌醇-钙第二信使系统介导。选择性剪接导致编码不同异构体的多个转录体变体，其中一些可能具有不同的功能。[由RefSeq提供]。