MARCKS polyclonal antibody
产品名称： MARCKS polyclonal antibody
英文名称： MARCKS polyclonal antibody
产品编号： PAB18486
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MARCKS.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S158 of human MARCKS.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to MARCKS.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF.
Saito T, Okada S, Ohshima K, Yamada E, Sato M, Uehara Y, Shimizu H, Pessin JE, Mori M.Endocrinology. 2004 Sep;145(9):4232-43. Epub 2004 Jun 10.
- 2.
- The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, CollierNature. 2003 Oct 23;425(6960):805-11.
- 3.
- Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.
Buerger C, Nagel-Wolfrum K, Kunz C, Wittig I, Butz K, Hoppe-Seyler F, Groner B.J Biol Chem. 2003 Sep 26;278(39):37610-21. Epub 2003 Jul 2.
- 4.
- Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis.
Wang XQ, Sun P, Paller AS.J Biol Chem. 2001 Nov 30;276(48):44504-11. Epub 2001 Sep 27.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from mouse brain cells, using MARCKS polyclonal antibody (Cat # PAB18486).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 4082
- Protein Accession#:
- P29966
- Gene Name:
- MARCKS
- Gene Alias:
- 80K-L,FLJ14368,FLJ90045,MACS,PKCSL,PRKCSL
- Gene Description:
- myristoylated alanine-rich protein kinase C substrate
- Omim ID:
- 177061
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq
- Other Designations:
- OTTHUMP00000017045,myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L),phosphomyristin
- Gene Pathway