FITC标记的HSD13蛋白抗体
产品名称： FITC标记的HSD13蛋白抗体
英文名称： Anti-FANK1/FITC
产品编号： HZ-6629R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FANK1/FITC Conjugated antibody
FITC标记的HSD13蛋白抗体
| 英文名称 | Anti-FANK1/FITC |
| 中文名称 | FITC标记的HSD13蛋白抗体 |
| 别 名 | Fank1; FANK1_HUMAN; Fibronectin type 3 and ankyrin repeat domains protein 1; Fibronectin type III and ankyrin repeat domains 1; HSD13. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FANK1 (61-110aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FANK1 (fibronectin type III and ankyrin repeat domains 1), also known as HSD13, is a 345 amino acid nuclear and cytoplasmic testis-specific protein found primarily in pachytene spermatocytes and round spermatids. Containing six ANK repeats and a single fibronectin type-III domain, FANK1 undergoes alternative splicing events to form three isoforms. Possessing DNA binding activity, FANK1 is suggested to act as a transcription factor and may regulate gene expression during spermatogenesis. The gene encoding FANK1 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Subcellular Location: Nucleus. Cytoplasm Tissue Specificity: Mostly restricted to testis. Similarity: Contains 6 ANK repeats. Contains 1 fibronectin type-III domain. Database links: UniProtKB/Swiss-Prot: Q8TC84.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FANK1（纤连蛋白III型和锚蛋白重复结构域1），也称为HSD13，是一种345个氨基酸的核和细胞质睾丸特异性蛋白，主要见于粗线精母细胞和圆形精子细胞。含有六个重复序列和一个单一纤连蛋白III型结构域，FANK1经历选择性剪接事件以形成三个亚型。FANK1具有DNA结合活性，可作为转录因子，可调控精子发生过程中的基因表达。编码FANK1的基因映射到人类10号染色体，该基因包含800个以上的基因和1亿3500万个核苷酸，构成了人类基因组的近4.5%。PTEN是一种重要的肿瘤抑制基因，位于10号染色体上，当有缺陷时，会引起癌症发展的遗传易感性，称为考登综合征。