FITC标记的紧密连接蛋白23抗体
产品名称： FITC标记的紧密连接蛋白23抗体
英文名称： Anti-Claudin 23/FITC
产品编号： HZ--13746R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Claudin 23/FITC Conjugated antibody
FITC标记的紧密连接蛋白23抗体
| 英文名称 | Anti-Claudin 23/FITC |
| 中文名称 | FITC标记的紧密连接蛋白23抗体 |
| 别 名 | 2310014B08Rik; Claudin23; CLDN 23; CLDN23; CLDNL; CLD23_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin 23 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-23, also known as CLDN23 or CLDNL, is a 292 amino acid multi-pass membrane protein that localizes to cell junctions and belongs to the claudin family. Expressed in stomach and placenta, as well as in germinal center B-cells, claudin-23 is thought to exhibit calcium-dependent cell-adhesion activity through which it plays an essential role in tight junction-specific obliteration of the intercellular space. Human claudin-23 shares 80% sequence similarity with its mouse counterpart, suggesting a conserved role between species. Overexpression of claudin-23 is associated with colon tumors, implicating claudin-23 as a possible metastasis factor. Subcellular Location: Integral membrane protein. Tight junctions Similarity: Belongs to the claudin family. Database links: Entrez Gene: 137075 Human Entrez Gene: 71908 Mouse Omim: 609203 Human SwissProt: Q96B33 Human SwissProt: Q9D7D7 Mouse Unigene: 183617 Human Unigene: 37817 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
克劳丁超家族由结构相关的蛋白质组成，这些蛋白质是紧密连接的重要结构和功能成分。Claudin-23，又称CLDN23或CLDNL，是一种292个氨基酸的多路膜蛋白，定位于细胞连接，属于Claudin家族。claudin-23在胃、胎盘和生发中心B细胞中均有表达，被认为具有钙依赖性细胞粘附活性，通过该活性，它在细胞间紧密连接特异性封闭中发挥重要作用。人CalDUB-23与小鼠的同源性有80%的序列相似性，表明物种间具有保守的作用。Caltuin 23的过度表达与结肠肿瘤相关，暗示CalDUB-23是可能的转移因子。