Stressmarq公司生产研发的Alpha Synuclein 蛋白是一款比较热销的产品，该产品货号为SPR-316。下文是对该产品的具体介绍，如需购买该产品，请联系一级代理商欣博盛生物。

产品名称：Alpha Synuclein 蛋白

产品描述：活性重组人Alpha Synuclein 蛋白单体 (2型)

应用范围：WB, SDS-PAGE, In vivo assay, In vitro assay

浓度：各批次不同，请详见说明书

标记物：无标签

性质：重组

来源物种：人

表达系统：大肠杆菌 (E. coli)

氨基酸序列：MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

纯度：>95%

蛋白长度：全长蛋白

Full Biological Activity:硫磺素 T 曲线显示当2型单体 (SPR-316) 被PFFs引起聚集时形成的 β-sheet 聚集要比1型单体 (SPR-321) 少.

储存缓冲液：PBS pH 7.4

储存温度：-80ºC

运输温度：干冰. 运输: 该产品会与其他同订单产品分开发货.

纯化方式：离子交换层析纯化

Protein Size：分子量约为14.46kDa.

引用该产品：Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences, Canada, Cat # SPR-316B)

分析证书：该蛋白已经通过SDS-PAGE检测证明纯度为95%.

其他相关信息：经 LAL assay检测，内毒素低于1EU/µg .

别名：Alpha Synuclein Protein, AlphaSyn Protein, NACP Protein, Non A4 component of amyloid Protein, PARK1 Protein, PARK4 Protein, SNCA Protein, SYN Protein, Parkison disease familial 1 Protein

研究领域：神经纤维缠结&Tau, 突触核蛋白, 神经生物学, 神经衰退疾病, 帕金森氏病, 阿尔茨海默病

细胞定位：细胞核, 细胞质, 膜

Accession Number ：NP_000336.1

GeneID：6622

Swiss Prot：P37840

科研背景：

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

参考资料：

1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).

2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.

3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.

4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231(1): 226-230.

5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.

6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

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